Symbol Name ID |
Tnfaip3
tumor necrosis factor, alpha-induced protein 3 MGI:1196377 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Hemolytic anemia |
Lymphopenia |
Thrombocytopenia |
Disease(s) Associated with TNFAIP3 | |||
familial Behcet-like autoinflammatory syndrome |
Mouse Phenotypes | hematopoietic system phenotype |
decreased B cell apoptosis |
increased B cell proliferation |
thymus atrophy |
enlarged spleen |
abnormal blood cell morphology/development |
increased immature B cell number |
abnormal myelopoiesis |
myeloid hyperplasia |
anemia |
increased myeloid cell number in bone marrow |
increased granulocyte number |
abnormal B cell number |
increased germinal center B cell number |
decreased mature B cell number |
decreased B-1a cell number |
decreased B-1b cell number |
decreased marginal zone B cell number |
increased follicular B cell number |
increased plasma cell number |
decreased B cell number |
increased B cell number |
increased CD4-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
increased effector memory T-helper cell number |
increased T cell number |
increased lymphocyte cell number |
increased macrophage cell number |
increased myeloid cell number |
abnormal B cell morphology |
abnormal B-1a B cell morphology |
abnormal spleen morphology |
increased splenocyte number |
pale spleen |
abnormal B cell activation |
increased IgA level |
increased IgG2a level |
increased IgG level |
increased IgM level |
increased immunoglobulin level |
increased microglial cell activation |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||
Tnfaip3m1Apb/Tnfaip3m1Apb | ||||||||||||||||||||||||||||||||||||||||||
Tnfaip3tm1.1Gho/Tnfaip3tm1.1Gho | ||||||||||||||||||||||||||||||||||||||||||
Tnfaip3tm1Ama/Tnfaip3tm1Ama | ||||||||||||||||||||||||||||||||||||||||||
Tnfaip3tm3.1Ama/Tnfaip3tm3.1Ama | ||||||||||||||||||||||||||||||||||||||||||
Tnfaip3tm4.1Ama/Tnfaip3tm4.1Ama | ||||||||||||||||||||||||||||||||||||||||||
Cd19tm1(cre)Cgn/Cd19+ Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai (conditional) |
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Tnfaip3tm1Homy/Tnfaip3tm1Homy Tg(Mx1-cre)1Cgn/? (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||
Gt(ROSA)26Sortm9(cre/ESR1)Arte/? Tnfaip3tm1Homy/Tnfaip3tm1Homy (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||
Tnfaip3tm2Ama/Tnfaip3tm2Ama Cd19tm1(cre)Cgn/Cd19+ (conditional) |
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Cd19tm1(cre)Cgn/Cd19+ Tnfaip3tm2Ama/Tnfaip3+ (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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